A brief history of microscopy: from 1595 to the electron beam

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Although it looks like a simple cylinder with a lens attached, thanks to the microscope we can see the presence of cells. Without it, biology would just be guessing. It makes the invisible visible. That’s it.

The story begins at the end of the 16th century. Dutch optician Zacharias Janssen is generally considered to be the inventor of the first microscope in 1595. However, some sources disagree. The concept of the magnifying glass is said to date back to the 15th century. But Janssen combined two convex lenses. One is for magnification. One is for the eyes. His father probably helped him. Insert two glass lenses into the slide. result? 10x magnifying glass.

Galileo was not far behind. By 1609, he had developed his own version. He used convex and concave lenses. He called it “occhiolino”. The word “microscope” itself did not appear until 1645. It was created by Demisiano. It comes from Greek. Micros means small. Skopein means “to see”.

Development of optical technology

The tools didn’t stay put. It got better. Faster. Sharper.

1667 年、ロバートフックは、今日しますますますますますますに似たとしましたますをを製一 added a step. focusing system. in the spotlight. He used three molded glass lenses instead of two. Thanks to this machine, he was able to discover cells. Hooke was a giant in this field.

クリスティアン・ホイヘンスは 17 世紀末にこれをさらに改良しまに改良しまししししししぢししししし 顕微鏡は好奇心から必需品になりました.生物学者や医師は病原体を見つけるためにそれを使用します。 He löysivät solun jakautumisen. They identified the bacilli that cause leprosy and tuberculosis. These discoveries led to the creation of the first vaccines.

The optical limit was reached for a long time. Then came the 1930s. The Germans Ernst Ruska and Max Knoll invented the electron microscope. It uses electrons instead of light. This breaks the resolution barrier of glass lenses. Scanning tunneling microscopes were introduced in the 1980s. Atomic force microscope. Digital microscope. The functionality is the same. Technology has completely changed.

How a microscope actually works

The goal is always the same. Create an enlarged image. There are different methods. Here are the main types you need to know about.

Optical microscope

Think of a camera. Optical microscopes use objective lenses made of several glass elements. Project the image onto the eyepiece. Isolate the details so your eye can process them. Currently there are more than a dozen types. The maximum magnification is 2000x. This is sufficient for most biological samples.

Electron microscope

Light does not work at the atomic level. Electrons do. An electron microscope illuminates the object with an electron beam. Interaction creates images. These machines are powerful. The best can be magnified 2 million times. You can see viruses. You can see atoms.

Atomic force microscope

This is a near-field microscope. It does not use light or electrons. It uses a physical tip. The tip touches the surface. It interacts with the atoms of the object. The software then reconstructs the 3D image. The resolution is in nanometers. You can feel the texture of a single molecule.

Digital microscope

These are cheap. They use digital cameras. The camera sends images to the screen via USB. You are not looking through the eyepiece. you are looking at the screen. It’s portable. Can be used anywhere. Ideal for on-site work and quick inspections.

Why microscopes are everywhere

You might think that microscopes are only for laboratories. They aren’t. They are everywhere. Anywhere you want to see small things, you need a microscope.

In biology, they show us life. Medicine diagnoses diseases. In forensics, they find evidence. Geologists use them to study rocks. Metallurgists check for structural defects. Gemologists examine diamonds for flaws that can affect their value. Even petrography depends on them.

Microscopes have changed the way we see reality. It shows that the world is made of small things. Smaller than we could ever imagine. We continue to create better transparent lenses.